(S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Base Information

Chemical Name:(S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea
CAS No.:1268473-78-4
Molecular Formula:C₂₂H₂₆N₆O₃
Molecular Weight:422.487
Hs Code.:

Synonyms:(S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

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Chemical Property of (S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

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Technology Process of (S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

There total 6 articles about (S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256446-67-0,819078-65-4
4-((benzyloxy)carbonyl)morpholine-3-carboxylic acid

: 1268473-78-4
(S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

: 1268473-79-5
(R)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 18 h / 34 - 50 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 5.03 h / -70 - -40 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 760.05 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -10 - 20 °C

5: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr

6: potassium carbonate / dimethyl sulfoxide / 2.5 h / 20 - 35 °C

7: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.67 h / 100 °C / Microwave Irradiation

8: ammonium acetate / isopropyl alcohol; water / Resolution of racemate

With methanol; sulfuric acid; ammonium acetate; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(acetylacetonate)oxovanadium; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 77873-76-8,106825-81-4
morpholine-3-carboxylic acid

: 1268473-78-4
(S)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

: 1268473-79-5
(R)-1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

2: sodium t-butanolate / dimethyl sulfoxide / 16.2 h / 20 °C / Cooling with ice

3: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.67 h / 100 °C / Microwave Irradiation

5: ammonium acetate / isopropyl alcohol; water / Resolution of racemate

With ammonium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; dimethyl sulfoxide; isopropyl alcohol;