6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

Base Information

Chemical Name:6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile
CAS No.:952206-77-8
Molecular Formula:C₂₇H₂₅Cl₂N₅O₂
Molecular Weight:522.434
Hs Code.:

Synonyms:6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

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Chemical Property of 6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

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Technology Process of 6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

There total 8 articles about 6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 952206-76-7
6-(2,4-dichloro-phenyl)-3-(6-fluoro-pyridin-3-yl)-8-isobutoxy-imidazo[1,2-a]pyridine-7-carbonitrile

: 952206-77-8
6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

Guidance literature:: In dimethyl sulfoxide; at 180 ℃; for 0.5h;

Reference yield:

: 944401-72-3
2-amino-5-bromoisonicotinonitrile

: 952206-77-8
6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / Heating / reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C

3.1: 0.28 h / 150 °C / Microwave irradiation

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: sodium hydride / 0.17 h / 0 - 20 °C

5.2: 1 h / 70 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation

7.1: dimethyl sulfoxide / 0.5 h / 180 °C

With N-chloro-succinimide; N-Bromosuccinimide; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Suzuki Coupling / 6.1: Suzuki Coupling;

Reference yield:

: 952206-43-8
2-amino-5-(2,4-dichloro-phenyl)-isonicotinonitrile

: 952206-77-8
6-(2,4-dichloro-phenyl)-8-isobutoxy-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C

2.1: 0.28 h / 150 °C / Microwave irradiation

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydride / 0.17 h / 0 - 20 °C

4.2: 1 h / 70 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation

6.1: dimethyl sulfoxide / 0.5 h / 180 °C

With N-chloro-succinimide; N-Bromosuccinimide; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;