diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester

Base Information

• Chemical Name: diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester
• CAS No.: 1020850-27-4
• Molecular Formula: C₁₂H₁₉O₆P
• Molecular Weight: 290.253
• Mol file: 1020850-27-4.mol

Synonyms:diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester

Chemical Property of diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester

There total 1 articles about diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diethylphosphonoacetic acid (3095-95-2) + 4-hydroxy-2-cyclohexenone (30182-12-8) → diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester (1020850-27-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 48h;

DOI:10.1002/anie.200705329

Reference yield: 60.0%

diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester (1020850-27-4) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → (3E)-syn-3-(3,4,5-trimethoxybenzylidene)tetrahydrobenzofuran-2,5(3H,4H)-dione

Guidance literature:

diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 0 ℃;

3,4,5-trimethoxy-benzaldehyde; In tetrahydrofuran; toluene; Further stages.; Heating;

DOI:10.1002/anie.200705329

Reference yield: 55.0%

diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester (1020850-27-4) + 4-Phenylbenzaldehyde (3218-36-8) → (3E)-syn-3-(biphenyl-4-yl-methylidene)tetrahydrobenzofuran-2,5(3H,4H)-dione

Guidance literature:

diethylphosphorylacetic acid 4-oxocyclohex-2-enyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 0 ℃;

4-Phenylbenzaldehyde; In tetrahydrofuran; toluene; Further stages.; Heating;

DOI:10.1002/anie.200705329

upstream raw materials:

diethylphosphonoacetic acid

4-hydroxy-2-cyclohexenone

Downstream raw materials:

C₉H₁₀O₃

Refernces

• 1、 Edwards, Michael G.,Kenworthy, Martin N.,Kitson, Russell R. A.,Perry, Alexis,Scott, Mark S.,Whitwood, Adrian C.,Taylor, Richard J. K.. "The preparation of α-alkylidene-γ-butyrolactones using a telescoped intramolecular Michael/Olefination (TIMO) sequence: Synthesis of (+)-paeonilactone B". experimental part. p. 4769 - 4783. Retrieved 2009/05/27.