N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

Base Information

Chemical Name:N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride
CAS No.:1029806-20-9
Molecular Formula:C₂₅H₂₈N₂O₄S*ClH
Molecular Weight:489.035
Hs Code.:

Synonyms:N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

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Chemical Property of N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

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Technology Process of N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

There total 2 articles about N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1029806-19-6
1-(2'-methanesulfonylaminobiphenyl-4-ylmethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 1029806-20-9
N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;

Reference yield:

: 606978-01-2
1-(4-Bromo-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 756520-78-2
(2-(methylsulfonyl)aminophenyl)boronic acid

: 1029806-20-9
N-[4'-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)biphenyl-2-yl]-methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / palladium diacetate; triphenylphosphine / isopropyl alcohol

2: hydrogenchloride / diethyl ether

With hydrogenchloride; sodium carbonate; palladium diacetate; triphenylphosphine; In diethyl ether; isopropyl alcohol; 1: Suzuki Coupling;