7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one

Base Information

• Chemical Name: 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one
• CAS No.: 1027915-95-2
• Molecular Formula: C₁₆H₁₅NO₃S
• Molecular Weight: 301.366
• Mol file: 1027915-95-2.mol

Synonyms:7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one

Chemical Property of 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one

There total 4 articles about 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methyl-3-(2-propoxy-benzoylamino)-thiophene-2-carboxylic acid (1026383-98-1) → 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one (1027915-95-2)

Guidance literature:

With thionyl chloride; In dichloromethane; Ambient temperature;

DOI:10.1021/jm950812j

Reference yield:

2-propoxybenzoyl chloride (54090-36-7) → 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one (1027915-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 6.8 g / pyridine

2: 5.5 g / 1 N NaOH / ethanol / 1.5 h / Heating

3: 4 g / SOCl₂ / CH₂Cl₂ / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; In ethanol; dichloromethane;

DOI:10.1021/jm950812j

Reference yield:

4-Methyl-3-(2-propoxy-benzoylamino)-thiophene-2-carboxylic acid methyl ester (1026402-32-3) → 7-Methyl-2-(2-propoxy-phenyl)-thieno[3,2-d][1,3]oxazin-4-one (1027915-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.5 g / 1 N NaOH / ethanol / 1.5 h / Heating

2: 4 g / SOCl₂ / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; thionyl chloride; In ethanol; dichloromethane;

DOI:10.1021/jm950812j

upstream raw materials:

4-Methyl-3-(2-propoxy-benzoylamino)-thiophene-2-carboxylic acid

2-propoxybenzoyl chloride

4-Methyl-3-(2-propoxy-benzoylamino)-thiophene-2-carboxylic acid methyl ester

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester