C₃₃H₃₃N₃O₆

Base Information

• Chemical Name: C₃₃H₃₃N₃O₆
• CAS No.: 1092803-49-0
• Molecular Formula: C₃₃H₃₃N₃O₆
• Molecular Weight: 567.642
• Mol file: 1092803-49-0.mol

Synonyms:C₃₃H₃₃N₃O₆

Chemical Property of C₃₃H₃₃N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₃N₃O₆

There total 4 articles about C₃₃H₃₃N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H47N3O6Si (1092804-55-1) → C33H33N3O6 (1092803-49-0)

Guidance literature:

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

(1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methylene-3-(uracil-1-yl)-2-oxabicyclo[2.2.1]heptane (1092803-47-8) → C33H33N3O6 (1092803-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: triethylamine; trichlorophosphate; 1,2,4-Triazole / acetonitrile / 5 h / 20 °C

2.2: 4 h / 20 °C

3.1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; 1,2,4-Triazole; triethylamine tris(hydrogen fluoride); triethylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(1R,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-5-methylene-3-(uracil-1-yl)-2-oxabicyclo[2.2.1]heptane (1092803-46-7) → C33H33N3O6 (1092803-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 16 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: triethylamine; trichlorophosphate; 1,2,4-Triazole / acetonitrile / 5 h / 20 °C

3.2: 4 h / 20 °C

4.1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 16 h / 20 °C

With pyridine; 1H-imidazole; 1,2,4-Triazole; triethylamine tris(hydrogen fluoride); triethylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(1R,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-5-methylene-3-(uracil-1-yl)-2-oxabicyclo[2.2.1]heptane

(1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methylene-3-(uracil-1-yl)-2-oxabicyclo[2.2.1]heptane

(1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-5-methylene-7-(triethylsilyloxy)-3-(uracil-1-yl)-2-oxabicyclo[2.2.1]heptane

C₃₉H₄₇N₃O₆Si

Downstream raw materials:

(1R,3R,4R,7S)-3-(4-N-benzoylcytosin-1-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methylene-2-oxabicyclo[2.2.1]heptane

(1R,3R,4R,7S)-3-(4-N-benzoylcytosin-1-yl)-7-[cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-5-methylene-2-oxabicyclo[2.2.1]heptane