N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide

Base Information

• Chemical Name: N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide
• CAS No.: 87661-79-8
• Molecular Formula: C₁₈H₁₈N₄O₄
• Molecular Weight: 354.365

Synonyms:N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide

Chemical Property of N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide

There total 5 articles about N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,2-diamino-benzene (95-54-5) + p-benzoquinone (106-51-4) + ascorbic acid (50-81-7,98966-42-8) → N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide (87661-79-8)

Guidance literature:

p-benzoquinone; ascorbic acid; In methanol; water; at 20 ℃; for 2h;

1,2-diamino-benzene; for 3h; Reflux;

DOI:10.1016/j.inoche.2016.05.019

Reference yield:

ascorbic acid (50-81-7,98966-42-8) → N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide (87661-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzoquinone / methanol; H₂O / 2 h / 20 °C

2: methanol; H₂O / 0.03 h / microwave irradiation

With p-benzoquinone; In methanol; water;

DOI:10.1080/07328300701252359

Reference yield:

3a,6-dihydroxy-tetrahydro-furo[3,2-b]furan-2,3-dione + 1,2-diamino-benzene (95-54-5) → N-(2-aminophenyl)-3-[(1S,2S)-1,2,3-trihydroxypropyl]quinoxaline-2-carboxamide (87661-79-8)

Guidance literature:

In methanol; water; for 0.0333333h; microwave irradiation;

DOI:10.1080/07328300701252359

upstream raw materials:

1,2-diamino-benzene

p-benzoquinone

ascorbic acid

L-dehydroascorbic acid

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