dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine

Base Information

• Chemical Name: dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine
• CAS No.: 925412-83-5
• Molecular Formula: C₄₂H₅₀N₄O
• Molecular Weight: 626.885
• Mol file: 925412-83-5.mol

Synonyms:dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine

Chemical Property of dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine

There total 5 articles about dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[4-(3-dimethylamino-propoxy)-phenyl]-1-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-one (925412-82-4) → dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine (925412-83-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine (151070-87-0) → dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine (925412-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: EDC; HOBT / CH₂Cl₂

2: 80 percent / 1,1-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

3: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; tributylphosphine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

3-(4-hydroxy-phenyl)-1-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-one (925412-45-9) → dimethyl-[3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-phenoxy)-propyl]-amine (925412-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 1,1-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.10.087

upstream raw materials:

3-[4-(3-dimethylamino-propoxy)-phenyl]-1-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-one

4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

3-(4-hydroxy-phenyl)-1-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-one

3-Dimethylamino-1-propanol