benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

Base Information

Chemical Name:benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate
CAS No.:909415-17-4
Molecular Formula:C₂₄H₂₆N₂O₆
Molecular Weight:438.48
Hs Code.:

Synonyms:benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

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Chemical Property of benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

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Technology Process of benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

There total 4 articles about benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 126430-46-4
benzyl 4-bromobutanoate

: 132391-70-9
(11aS)-8-hydroxy-7-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

: 909415-17-4
benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm051199z

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 909415-17-4
benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2; DMF / CH₂Cl₂

2: 1.318 g / Et₃N / CH₂Cl₂ / 4 h / -30 - 20 °C

3: 88 percent / H₂ / Pd/C / ethanol / 3 h / 2585.74 Torr

4: 62 percent / K₂CO₃ / dimethylformamide / 20 °C

With oxalyl dichloride; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051199z

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 909415-17-4
benzyl (11aS)-4-(7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.318 g / Et₃N / CH₂Cl₂ / 4 h / -30 - 20 °C

2: 88 percent / H₂ / Pd/C / ethanol / 3 h / 2585.74 Torr

3: 62 percent / K₂CO₃ / dimethylformamide / 20 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051199z