5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Base Information

Chemical Name:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid
CAS No.:1414472-86-8
Molecular Formula:C₂₉H₂₆ClN₅O₇S₃
Molecular Weight:688.206
Hs Code.:

Synonyms:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

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Chemical Property of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

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Technology Process of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

There total 5 articles about 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1414468-76-0
{5-[6-(5-amino-6-methoxypyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]thiophen-2-ylmethyl}carbamic acid tert-butyl ester

: 137-64-4
2-chloro-5-(chlorosulfonyl)benzoic acid

: 1414472-86-8
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:: With pyridine; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/acsmedchemlett.1c00412

Reference yield: 60.0%

: 1414472-86-8
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:

Reference yield:

: 16269-66-2
4-chlorothieno[3,2-d]pyrimidine

: 1414472-86-8
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 2 h / -50 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 2 h / 120 °C / Sealed tube

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Sealed tube

4.1: pyridine / 3.5 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.1c00412