2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione
• CAS No.: 143429-81-6
• Molecular Formula: C₂₅H₂₇N₃O₃S
• Molecular Weight: 449.574

Synonyms:2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione

Chemical Property:

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Technology Process of 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione

There total 2 articles about 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

phthalimide (136918-14-4,85-41-6) + 3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>-1,2,4-thiadiazole-5-methanol (143429-78-1) → 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione (143429-81-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 16h;

DOI:10.1021/jm00098a015

Reference yield:

ethyl 3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>-1,2,4-thiadiazole-5-carboxylate (143429-77-0) → 2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione (143429-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaBH₄ / methanol / 16 h

2: 67 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 16 h

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm00098a015

Reference yield:

2-<<3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenol>-1,2,4-thiadiazol-5-yl>methyl>-1H-isoindole-1,3(2H)-dione (143429-81-6) → 4-(5-Aminomethyl-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-butyl-phenol (143429-79-2)

Guidance literature:

With hydrazine; In ethanol; at 80 ℃; for 1.5h;

DOI:10.1021/jm00098a015

upstream raw materials:

phthalimide

3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>-1,2,4-thiadiazole-5-methanol

ethyl 3-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>-1,2,4-thiadiazole-5-carboxylate

Downstream raw materials:

4-(5-Aminomethyl-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-butyl-phenol

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