(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

Base Information

Chemical Name:(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide
CAS No.:884867-04-3
Molecular Formula:C₁₇H₂₅N₃O₂
Molecular Weight:303.404
Hs Code.:

Synonyms:(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

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Chemical Property of (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

Chemical Property:

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Technology Process of (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

There total 7 articles about (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869307-51-7
N-benzyloxycarbonyl-L-valyl-L-proline benzylamide

: 884867-04-3
(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 3h; under 1551.44 Torr;
DOI:10.1021/jm0500830

Reference yield:

: 3496-11-5
2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate

: 884867-04-3
(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77.7 percent / Et₃N / tetrahydrofuran; H₂O / 20 °C

2.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

2.2: 75.5 percent / tetrahydrofuran / 20 °C

3.1: H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

With N-ethylmorpholine;; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm0500830

Reference yield:

: 47450-18-0,68166-40-5,53331-43-4
N-benzyloxycarbonyl-L-valyl-L-proline

: 884867-04-3
(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

1.2: 75.5 percent / tetrahydrofuran / 20 °C

2.1: H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830