(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Base Information

Chemical Name:(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide
CAS No.:1124214-95-4
Molecular Formula:C₂₆H₃₅FN₄O₂
Molecular Weight:454.588
Hs Code.:

Synonyms:(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Suppliers and Price of (S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

There total 5 articles about (S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124214-97-6
(S)-(4-amino-3-fluorophenyl)(3-isopropylpiperazin-1-yl)methanone

: 1124214-95-4
(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 3h; Reflux;

Reference yield:

: 674792-05-3,886766-25-2
(S)-tert-butyl 2-isopropylpiperazine-1-carboxylate

: 1124214-95-4
(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane; ethyl acetate / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: potassium carbonate / sodium iodide / acetonitrile / 3 h / Reflux

With potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 1124214-95-4
(S)-3-((4-(4-amino-3-fluorobenzoyl)-2-isopropylpiperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2: potassium carbonate / sodium iodide / acetonitrile / 3 h / Reflux

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; acetonitrile;