(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

Base Information

Chemical Name:(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone
CAS No.:78829-10-4
Molecular Formula:C₁₇H₂₅BrN₂O₂S
Molecular Weight:401.368
Hs Code.:

Synonyms:(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

Chemical Property:

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Technology Process of (+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

There total 8 articles about (+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 78964-92-8
(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 78829-10-4
(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

Guidance literature:: In diethyl ether; 0 deg C -> RT;
DOI:10.1021/ja00408a007

Reference yield:

: 585-34-2
3-tert-butylphenyol

: 78829-10-4
(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / 5percent Rh/C / methanol

2: 89 percent / CrO₃-H₂SO₄ / acetone

3: 1.) LiAlH₄, 2.) pyridine / 1.) Et₂O

4: 1.) brucine / 2.) saponification

5: 94 percent / Jones reagent

6: 1.) lithium diisopropylamide, 2) Me₃SiCl, 3.) Br₂ / 1.) THF, -78 deg C, 25 min, 2.) RT, 20 min, 3.) CCl₄, -15 deg C, 15 min

7: 79 percent / diethyl ether / 0 deg C -> RT

With pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; chloro-trimethyl-silane; jones reagent; sulfuric acid; hydrogen; bromine; brucine; lithium diisopropyl amide; Rh on carbon; In methanol; diethyl ether; acetone;
DOI:10.1021/ja00408a007

Reference yield:

: 57287-85-1
(3S)-3-tert-butylcyclohexanone

: 78829-10-4
(+)-trans-(2R)-bromo-(5R)-tert-butylcyclohexanone p-toluenesulfonylhydrazone

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Rh/C

2: 94 percent / Jones reagent

3: 1.) lithium diisopropylamide, 2) Me₃SiCl, 3.) Br₂ / 1.) THF, -78 deg C, 25 min, 2.) RT, 20 min, 3.) CCl₄, -15 deg C, 15 min

4: 79 percent / diethyl ether / 0 deg C -> RT

With chloro-trimethyl-silane; jones reagent; hydrogen; bromine; lithium diisopropyl amide; Rh on carbon; In diethyl ether;
DOI:10.1021/ja00408a007