{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester
CAS No.:252354-02-2
Molecular Formula:C₂₀H₂₈F₃N₃O₂
Molecular Weight:399.456
Hs Code.:

{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of {3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

There total 7 articles about {3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 252354-01-1
4-[(3-azido-4,4,4-trifluoro-butyl)-benzyl-amino]-butyronitrile

: 252354-02-2
{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 15h; under 3000.24 Torr;
DOI:10.1021/jm991043x

Reference yield:

: 252353-98-3
4-benzylamino-1,1,1-trifluoro-butan-2-ol

: 252354-02-2
{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h

3: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

4: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

With sodium azide; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In dichloromethane; dimethyl sulfoxide; ethyl acetate; butan-1-ol; 1: Alkylation / 2: Mesylation / 3: Substitution / 4: Reduction-tert-butyloxycarbonylation;
DOI:10.1021/jm991043x

Reference yield:

: 252353-97-2
4-dibenzylamino-1,1,1-trifluoro-butan-2-ol

: 252354-02-2
{3-[benzyl-(3-cyano-propyl)-amino]-1-trifluoromethyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10 percent Pd/C / methanol / 6 h / 20 °C / 760 Torr

2: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

3: Et₃N / CH₂Cl₂ / 1 h

4: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

5: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

With sodium azide; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; butan-1-ol; 1: Hydrogenolysis / 2: Alkylation / 3: Mesylation / 4: Substitution / 5: Reduction-tert-butyloxycarbonylation;
DOI:10.1021/jm991043x