(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

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Chemical Name:(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol
CAS No.:130759-99-8
Molecular Formula:C₄₅H₈₈O₄Si₃
Molecular Weight:777.448
Hs Code.:

(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

Synonyms:(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

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Chemical Property of (R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

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Technology Process of (R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

There total 8 articles about (R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66774-84-3
de-A,B-25-hydroxycholestan-8β-ol

: 130759-99-8
(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / pyridine / 96 h / Ambient temperature

2: 2,6-lutidine / CH₂Cl₂ / 0.5 h / Ambient temperature

3: diisobutylaluminum hydride / CH₂Cl₂ / 1 h / -78 °C

4: pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

5: 1) LDA, 2) (CO₂H)2 / 1) THF, -78 deg C to 20 deg C, 2) 1.5h, r.t.

6: 1) CrCl₃, LiAlH₄, 2) DIBAL / 1) THF, 0 deg C, 10 min to r.t., 45 min, 2) CH₂Cl₂, -50 deg C, 30 min

With pyridine; 2,6-dimethylpyridine; chromium chloride; lithium aluminium tetrahydride; oxalic acid; diisobutylaluminium hydride; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00001a092

Reference yield:

: 70550-66-2
<1R-<1β(R*),3aα,4β,7aβ>>-Octahydro-4-acetoxy-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol

: 130759-99-8
(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / Ambient temperature

2: diisobutylaluminum hydride / CH₂Cl₂ / 1 h / -78 °C

3: pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

4: 1) LDA, 2) (CO₂H)2 / 1) THF, -78 deg C to 20 deg C, 2) 1.5h, r.t.

5: 1) CrCl₃, LiAlH₄, 2) DIBAL / 1) THF, 0 deg C, 10 min to r.t., 45 min, 2) CH₂Cl₂, -50 deg C, 30 min

With 2,6-dimethylpyridine; chromium chloride; lithium aluminium tetrahydride; oxalic acid; diisobutylaluminium hydride; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00001a092

Reference yield:

: 130759-98-7
<1R-<1β(R*),3aα,4β,7aβ>>-Octahydro-1-<5-<<1,1-(dimethylethyl)dimethylsilyl>oxy>-1,5-dimethylhexyl>-7a-methyl-1H-inden-4-ol

: 130759-99-8
(R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) LDA, 2) (CO₂H)2 / 1) THF, -78 deg C to 20 deg C, 2) 1.5h, r.t.

3: 1) CrCl₃, LiAlH₄, 2) DIBAL / 1) THF, 0 deg C, 10 min to r.t., 45 min, 2) CH₂Cl₂, -50 deg C, 30 min

With chromium chloride; lithium aluminium tetrahydride; oxalic acid; diisobutylaluminium hydride; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00001a092