N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

Base Information

• Chemical Name: N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine
• CAS No.: 948579-46-2
• Molecular Formula: C₃₃H₄₃N₆O₈PSi
• Molecular Weight: 710.799

Synonyms:N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

Chemical Property of N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

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Technology Process of N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

There total 1 articles about N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester (61989-17-1) + N6-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine (51549-39-4) → N6-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine (948579-46-2)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide;

DOI:10.1016/j.bmcl.2007.05.071

Reference yield: 85.0%

N6-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine (948579-46-2) → 5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

Guidance literature:

With ammonia; In methanol;

DOI:10.1016/j.bmcl.2007.05.071

Reference yield:

N6-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine (948579-46-2) → 3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₃ / methanol

2: 99 percent / Et₃N*HF / tetrahydrofuran

With ammonia; triethylamine hydrofluoride; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2007.05.071

upstream raw materials:

N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester

N⁶-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine

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