2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Base Information

Chemical Name:2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide
CAS No.:229005-57-6
Molecular Formula:C₃₆H₄₃N₃O₂
Molecular Weight:549.756
Hs Code.:

Synonyms:2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Suppliers and Price of 2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

There total 16 articles about 2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 229007-09-4
4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]aniline

: 229007-65-2
2-(4-piperidinophenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid

: 229005-57-6
2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃;
DOI:10.1021/jm9906264

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 229005-57-6
2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N; NaBH(OAc)3 / 1,2-dichloro-ethane / 8 h / 20 °C

2: 100 percent / aq. NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

3: 79 percent / Fe; AcOH / 20 °C

4: 62 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine / 20 °C

With dmap; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dichloro-ethane; 1: reductive amination / 2: reductive amination / 3: Reduction / 4: Acylation;
DOI:10.1021/jm9906264

Reference yield:

: 5205-39-0
ethyl glutaroyl chloride

: 229005-57-6
2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: AlCl₃ / 3.5 h / 20 °C

2: 2 N aq. NaOH / methanol / 1.5 h / Heating

3: 73 percent / triethylsilane; TFA / 48 h / 55 °C

4: 67 percent / polyphosphoric acid / 12 h / 100 °C

5: 64 percent / NaOMe / 8 h / Heating

6: 86 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / -10 °C

7: Et₃N / CH₂Cl₂ / 20 °C

8: 74 percent / DBU / CH₂Cl₂ / 0.5 h / 20 °C

9: 70 percent / tetrakis(triphenylphosphine)palladium; 2 M aq. K₂CO₃ / ethanol; toluene / Heating

10: 100 percent / 1 N aq. NaOH / methanol; tetrahydrofuran / 20 °C

11: 62 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine / 20 °C

With triethylsilane; dmap; sodium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; PPA; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 1: Friedel-Crafts reaction / 2: Hydrolysis / 3: Reduction / 4: intramolecular Friedel-Crafts reaction / 5: methoxycarbonylation / 6: Reduction / 7: mesylation / 8: Elimination / 9: Suzuki coupling / 10: Hydrolysis / 11: Acylation;
DOI:10.1021/jm9906264