2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

Base Information

Chemical Name:2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide
CAS No.:792921-52-9
Molecular Formula:C₂₈H₄₅NO₄
Molecular Weight:459.67
Hs Code.:

Synonyms:2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

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Technology Process of 2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

There total 4 articles about 2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1575-74-2
(+-)-2-methyl-pent-4-enoic acid

: 503559-67-9
2-methylpenta-2,4-dienoic acid (2,4,5-trimethoxy-3-tridec-12-enylphenyl)amide

: 792921-52-9
2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2004.06.147

Reference yield:

: 135-77-3
1,2,4-trimethoxy-benzene

: 792921-52-9
2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / n-BuLi / tetrahydrofuran; hexane / 14 h / 20 °C

2: 94 percent / HNO₃; AcOH / 1 h / 20 °C

3: 83 percent / Sn; aq. HCl / 2 h / 60 °C

4: 63 percent / HATU; HOAt; DIPEA / dimethylformamide / 0.5 h / 0 - 20 °C

5: 69 percent / DCC; HOBT; DIPEA / dimethylformamide / 48 h / 20 °C

With hydrogenchloride; tin; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; nitric acid; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.06.147

Reference yield:

: 503559-71-5
13-iodotridec-1-ene

: 792921-52-9
2-methyl-pent-4-enoic acid (2,4,5-trimethoxy-3-tridec-12-enyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / n-BuLi / tetrahydrofuran; hexane / 14 h / 20 °C

2: 94 percent / HNO₃; AcOH / 1 h / 20 °C

3: 83 percent / Sn; aq. HCl / 2 h / 60 °C

4: 63 percent / HATU; HOAt; DIPEA / dimethylformamide / 0.5 h / 0 - 20 °C

5: 69 percent / DCC; HOBT; DIPEA / dimethylformamide / 48 h / 20 °C

With hydrogenchloride; tin; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; nitric acid; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.06.147