Technology Process of 3'-(AMINOMETHYL)-BIPHENYL-3-CARBOXYLIC ACID TERT-BUTYL ESTER
There total 11 articles about 3'-(AMINOMETHYL)-BIPHENYL-3-CARBOXYLIC ACID TERT-BUTYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
Pd-BaSO4;
In
methanol;
under 760 Torr;
DOI:10.1021/jm950414g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 80 °C
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 20 °C
4: triphenylphosphine / tetrahydrofuran; water / 4 h / 70 °C
With
sodium azide; sodium carbonate; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
1: Suzuki-Miyaura coupling reaction;
DOI:10.1055/s-2006-939059
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 79 percent / aq. K2CO3, Pd(OAc)2 / acetone / Heating
2: 97 percent
3: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight
4: 1.) N-bromosuccinimide, dibenzoyl peroxide, 2.) sodium azide / 1.) CCl4, reflux, 1.5 h, 2.) DMSO, 80 deg C, 4 h
5: 73 percent / H2 / 5percent Pd/BaSO4 / methanol / 760 Torr
With
palladium diacetate; N-Bromosuccinimide; n-butyllithium; sodium azide; hydrogen; potassium carbonate; dibenzoyl peroxide;
Pd-BaSO4;
In
methanol; acetone;
DOI:10.1021/jm950414g
