5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide

Base Information

• Chemical Name: 5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide
• CAS No.: 1227193-49-8
• Molecular Formula: C₂₁H₂₇N₃O₃
• Molecular Weight: 369.464

Synonyms:5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide

Chemical Property of 5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide

Chemical Property:

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Technology Process of 5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide

There total 1 articles about 5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-{5-[((S)-cyclohexylmethylcarbamoylmethyl)carbamoyl]furan-2-yl}benzyl)carbamic acid tert-butyl ester (1227193-48-7) → 5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide (1227193-49-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2010.07.036

Reference yield: 63.0%

5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide (1227193-49-8) + Isopropyl isocyanate (1795-48-8) → N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-(3-{[(propan-2-ylcarbamoyl)amino]methyl}phenyl)furan-2-carboxamide (1227190-72-8)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 54.0%

5-(3-aminomethylphenyl)furan-2-carboxylic acid ((S)-cyclohexylmethylcarbamoylmethyl)amide (1227193-49-8) + isobutyl chloroformate (543-27-1) → 2-methylpropyl [3-(5-{[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl}furan-2-yl)benzyl]carbamate (1227190-74-0)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

(3-{5-[((S)-cyclohexylmethylcarbamoylmethyl)carbamoyl]furan-2-yl}benzyl)carbamic acid tert-butyl ester

Downstream raw materials:

N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-(3-{[(propan-2-ylcarbamoyl)amino]methyl}phenyl)furan-2-carboxamide

2-methylpropyl [3-(5-{[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl}furan-2-yl)benzyl]carbamate

C₂₆H₃₀N₄O₄S

N-[3-(5-{[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl}furan-2-yl)benzyl]-1-methyl-1H-pyrazole-4-carboxamide

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