4-Amino-5-iodo-2-methoxybenzonitrile

Base Information

Chemical Name:4-Amino-5-iodo-2-methoxybenzonitrile
CAS No.:380241-63-4
Molecular Formula:C₈H₇IN₂O
Molecular Weight:274.061
Hs Code.:
DSSTox Substance ID:DTXSID901290051

Synonyms:380241-63-4;4-amino-5-iodo-2-methoxy-benzonitrile;4-Amino-5-iodo-2-methoxybenzonitrile;SCHEMBL1980619;JKQUTVNTVHNPAB-UHFFFAOYSA-N;DTXSID901290051;4-amino-5-iodo-2-(methyloxy)benzonitrile

Suppliers and Price of 4-Amino-5-iodo-2-methoxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 4-Amino-5-iodo-2-methoxybenzonitrile

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:273.96031
Heavy Atom Count:12
Complexity:201

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1C#N)I)N

Technology Process of 4-Amino-5-iodo-2-methoxybenzonitrile

There total 4 articles about 4-Amino-5-iodo-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7251-09-4
4-amino-2-methoxybenzonitrile

: 380241-63-4
4-amino-5-iodo-2-methoxybenzonitrile

Guidance literature:: With N-iodo-succinimide; acetic acid; for 2h;
DOI:10.1021/jm010244+

Reference yield:

: 101084-96-2
2-methoxy-4-nitrobenzonitrile

: 380241-63-4
4-amino-5-iodo-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₂*2H₂O; 6 N aq. HCl / dioxane / 3 h / 0 °C

2: 1.3 g / NIS; AcOH / 2 h

With hydrogenchloride; N-iodo-succinimide; acetic acid; tin(ll) chloride; In 1,4-dioxane;
DOI:10.1021/jm010244+

Reference yield:

: 2620-44-2
5-nitro-1,3-benzodioxole

: 380241-63-4
4-amino-5-iodo-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 31 percent / hexamethylphosphoric acid triamide / 0.5 h / 150 °C

2: 89 percent / K₂CO₃ / dimethylformamide / 2 h

3: SnCl₂*2H₂O; 6 N aq. HCl / dioxane / 3 h / 0 °C

4: 1.3 g / NIS; AcOH / 2 h

With hydrogenchloride; N-iodo-succinimide; potassium carbonate; acetic acid; tin(ll) chloride; In 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+