C₂₉H₃₃FN₄O₄

Base Information

• Chemical Name: C₂₉H₃₃FN₄O₄
• CAS No.: 1367127-34-1
• Molecular Formula: C₂₉H₃₃FN₄O₄
• Molecular Weight: 520.604
• Mol file: 1367127-34-1.mol

Synonyms:C₂₉H₃₃FN₄O₄

Chemical Property of C₂₉H₃₃FN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₃FN₄O₄

There total 12 articles about C₂₉H₃₃FN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 6-(4-(4-fluorophenoxy)phenyl)-4-(piperazin-1-ylmethyl)picolinamide dihydrochloride → C29H33FN4O4 (1367127-34-1)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → C29H33FN4O4 (1367127-34-1)

Guidance literature:

Multi-step reaction with 9 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 100 °C

3: N,N-Dimethylcarbamoyl chloride / dichloromethane / 12 h / 20 °C

4: sodium tetrahydroborate; methanol / 0 °C

5: triethylamine / dichloromethane / 6 h / 20 °C

6: triethylamine / dichloromethane / 12 h / 20 °C

7: water / PtH(PMe₂O)2(PMe₂(OH)) / ethanol / 0.25 h / 100 °C / Microwave irradiation

8: hydrogenchloride / ethyl acetate; 1,4-dioxane / 12 h / 20 °C

9: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 50 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; dimethylaminoacetic acid; water; sodium hexamethyldisilazane; potassium carbonate; caesium carbonate; triethylamine; N,N-Dimethylcarbamoyl chloride; tri tert-butylphosphoniumtetrafluoroborate; copper(l) iodide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

4-Fluorophenol (371-41-5) → C29H33FN4O4 (1367127-34-1)

Guidance literature:

Multi-step reaction with 9 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 100 °C

3: N,N-Dimethylcarbamoyl chloride / dichloromethane / 12 h / 20 °C

4: sodium tetrahydroborate; methanol / 0 °C

5: triethylamine / dichloromethane / 6 h / 20 °C

6: triethylamine / dichloromethane / 12 h / 20 °C

7: water / PtH(PMe₂O)2(PMe₂(OH)) / ethanol / 0.25 h / 100 °C / Microwave irradiation

8: hydrogenchloride / ethyl acetate; 1,4-dioxane / 12 h / 20 °C

9: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 50 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; dimethylaminoacetic acid; water; sodium hexamethyldisilazane; potassium carbonate; caesium carbonate; triethylamine; N,N-Dimethylcarbamoyl chloride; tri tert-butylphosphoniumtetrafluoroborate; copper(l) iodide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; toluene;

upstream raw materials:

1-Bromo-4-fluorobenzene

bromoacetic acid tert-butyl ester

4-Fluorophenol

4-pyridinecarboxylic acid, methyl ester