Technology Process of (1S,6S,8R)-8-(4-phenylbutyl)-2,9,10-trioxa-1phosphabicyclo[4.3.1]dec-4-ene 1-oxide
There total 1 articles about (1S,6S,8R)-8-(4-phenylbutyl)-2,9,10-trioxa-1phosphabicyclo[4.3.1]dec-4-ene 1-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4S,6S)-4,6-diethenyl-2-(2-propen-1-yloxy)-1,3,2-dioxaphosphorinane 2-oxide;
With
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane;
for 0.75h;
Inert atmosphere;
Reflux;
4-Phenylbut-1-ene;
With
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane; 1,2-dichloro-ethane;
at 60 - 70 ℃;
for 4h;
Inert atmosphere;
With
2-nitrobenzenesulfonyl hydrazide; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane;
at 20 ℃;
for 15h;
Inert atmosphere;
DOI:10.1021/ol403110p
- Guidance literature:
-
(1S,6S,8R)-8-(4-phenylbutyl)-2,9,10-trioxa-1phosphabicyclo[4.3.1]dec-4-ene 1-oxide;
With
formic acid; palladium diacetate; caesium carbonate; triphenylphosphine;
In
tetrahydrofuran;
at 40 ℃;
for 1h;
Inert atmosphere;
dimethyl sulfate;
In
tetrahydrofuran;
at 40 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol403110p
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triphenylphosphine; caesium carbonate; palladium diacetate; formic acid / tetrahydrofuran / 1 h / 40 °C / Inert atmosphere
1.2: 3 h / 40 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; formic acid; palladium diacetate; caesium carbonate; triphenylphosphine;
In
tetrahydrofuran;
DOI:10.1021/ol403110p
