(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Base Information

Chemical Name:(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate
CAS No.:1415580-95-8
Molecular Formula:C₄₈H₆₁N₇O₇S₂Si
Molecular Weight:940.273
Hs Code.:

(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Synonyms:(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

There total 10 articles about (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1137735-74-0
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

: 1415580-89-0
2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)aceticacid

: 1415580-95-8
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml300371t

Reference yield:

: 1415580-91-4
tert-butyl ((4-(2H-tetrazol-5-yl)thiazol-2-yl)methyl)carbamate

: 1415580-95-8
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 12 h / Inert atmosphere

2: lithium hydroxide / water; methanol / 1 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 12 h / 20 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; water; acetonitrile;
DOI:10.1021/ml300371t

Reference yield:

: 251294-64-1
2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile

: 1415580-95-8
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; zinc dibromide / water; tert-butyl alcohol / 1 h / 90 °C / Inert atmosphere

2: triethylamine / acetonitrile / 12 h / Inert atmosphere

3: lithium hydroxide / water; methanol / 1 h / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / 12 h / 20 °C / Inert atmosphere

With sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; lithium hydroxide; In methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ml300371t