N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

Base Information

Chemical Name:N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine
CAS No.:127019-45-8
Molecular Formula:C₁₈H₁₅N₃O₂S
Molecular Weight:337.402
Hs Code.:

Synonyms:N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

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Technology Process of N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

There total 3 articles about N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 3182-95-4
L-Phenylalaninol

: 116538-94-4
3-carbomethoxy-5-cyanothieno<2,3-b>pyridine

: 127019-45-8
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

Guidance literature:: In toluene; for 48h; Heating;
DOI:10.1002/jhet.5570260616

Reference yield:

: 40357-96-8
5-nitro-thiophene-3-carboxylic acid

: 127019-45-8
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

2: 15 percent / toluene / 48 h / Heating

With hydrogenchloride; tin; In toluene;
DOI:10.1002/jhet.5570260616

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 127019-45-8
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / HNO₃, H₂SO₄ / -10 - -5 °C

2: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

3: 15 percent / toluene / 48 h / Heating

With hydrogenchloride; tin; sulfuric acid; nitric acid; In toluene;
DOI:10.1002/jhet.5570260616