N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

Base Information

Chemical Name:N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine
CAS No.:1065479-36-8
Molecular Formula:C₂₁H₁₃ClF₃N₇
Molecular Weight:455.829
Hs Code.:

Synonyms:N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

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Chemical Property of N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

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Technology Process of N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

There total 9 articles about N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.3%

: 1065481-59-5
(5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methanamine

: 87-42-3,111055-92-6
6-chloro-7H-purine

: 1065479-36-8
N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 75 ℃; for 19h;

Reference yield:

: 1065483-00-2
3,5-dichloro-2-methylquinoxaline

: 1065479-36-8
N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 13.5 h / 100 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 21.5 h / Heating / reflux

3: sodium azide / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: hydrogen / palladium on activated carbon / methanol / 0.75 h

5: N-ethyl-N,N-diisopropylamine / ethanol / 19 h / 75 °C

With sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated carbon; In methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1065483-34-2
8-chloro-3-methylquinoxalin-2(1H)-one

: 1065479-36-8
N-((5-chloro-3-(2-(trifluoromethyl)phenyl)quinoxalin-2-yl)methyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 3 h / 100 °C

1.2: 0 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 13.5 h / 100 °C

3.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 21.5 h / Heating / reflux

4.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: hydrogen / palladium on activated carbon / methanol / 0.75 h

6.1: N-ethyl-N,N-diisopropylamine / ethanol / 19 h / 75 °C

With sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated carbon; In methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;