4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Base Information

Chemical Name:4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid
CAS No.:1434271-68-7
Molecular Formula:C₂₇H₂₂N₂O₃
Molecular Weight:422.483
Hs Code.:

Synonyms:4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

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Chemical Property of 4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

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Technology Process of 4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

There total 5 articles about 4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1434271-67-6
3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one

: 14047-29-1
4-carboxyphenylboronic acid

: 1434271-68-7
4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 4h;

Reference yield: 30.0%

: 586-76-5
4-Bromobenzoic acid

: 1434271-67-6
3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one

: 1434271-68-7
4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 4h;

Reference yield:

: 34231-77-1
methyl pyridazine-4-carboxylate

: 1434271-68-7
4'-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropyl amide / ethylbenzene; tetrahydrofuran; n-heptane / 0.08 h / -5 - 0 °C

2: triethylamine / tetrahydrofuran / 6 h / 0 °C

3: copper(l) iodide / diethyl ether; tetrahydrofuran / 1.75 h / 0 °C

4: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; n-heptane; ethylbenzene; water;