N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

Base Information

Chemical Name:N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide
CAS No.:952194-79-5
Molecular Formula:C₁₆H₁₈ClNO₅S
Molecular Weight:371.842
Hs Code.:

Synonyms:N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

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Chemical Property of N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

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Technology Process of N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

There total 5 articles about N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 952194-78-4
N-(2-chloro-5-formyl-phenyl)-3,4-dimethoxy-benzenesulfonamide

: 917-54-4
methyllithium

: 952194-79-5
N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

Guidance literature:: N-(2-chloro-5-formyl-phenyl)-3,4-dimethoxy-benzenesulfonamide; methyllithium; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; ethyl acetate; at 20 ℃;

Reference yield:

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 952194-79-5
N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / ethanol / 2 h / 20 °C

2: hydrogenchloride; iron / methanol; water / 6 h / 65 °C / Heating / reflux

3: pyridine / 20 °C

4: manganese(IV) oxide / tetrahydrofuran; dichloromethane / 6 h / 20 °C

5: tetrahydrofuran; diethyl ether / 0.5 h / -78 - 20 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; iron; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: 952194-77-3
N-(2-chloro-5-hydroxymethyl-phenyl)-3,4-dimethoxy-benzenesulfonamide

: 952194-79-5
N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / tetrahydrofuran; dichloromethane / 6 h / 20 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / -78 - 20 °C

With manganese(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane;