ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

Base Information

Chemical Name:ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate
CAS No.:168965-74-0
Molecular Formula:C₁₉H₃₀N₂O₄
Molecular Weight:350.458
Hs Code.:

Synonyms:ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

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Chemical Property of ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

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Technology Process of ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

There total 7 articles about ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 168965-73-9
ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(formylamino)phenyl>propanoate

: 168965-74-0
ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

Guidance literature:: With borane; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/ja953578v

Reference yield:

: 63307-45-9
1-(3-bromopropyl)-2-nitrobenzene

: 168965-74-0
ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / NaH / dimethylformamide / 20 h / Ambient temperature

2: HCl, AcOH / 9 h / Heating

3: SOCl₂ / 6 h / Ambient temperature

4: CH₂Cl₂ / 36 h / Ambient temperature

5: H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr / Ambient temperature

6: tetrahydrofuran / 4.5 h / Ambient temperature

7: 88 percent / BH₃ / tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; thionyl chloride; borane; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja953578v

Reference yield:

: 2-Amino-5-(2-nitro-phenyl)-pentanoic acid

: 168965-74-0
ethyl 2-<(tert-butoxycarbonyl)amino>-5-<2-(methylamino)phenyl>propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 6 h / Ambient temperature

2: CH₂Cl₂ / 36 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr / Ambient temperature

4: tetrahydrofuran / 4.5 h / Ambient temperature

5: 88 percent / BH₃ / tetrahydrofuran / 2 h / 0 °C

With thionyl chloride; borane; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja953578v