3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

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Chemical Name:3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide
CAS No.:1354954-88-3
Molecular Formula:C₂₈H₂₄N₆O₅
Molecular Weight:524.536
Hs Code.:

Synonyms:3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

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Chemical Property of 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

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Technology Process of 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

There total 7 articles about 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 274-47-5
imidazo[1,5-a]pyridine

: 1354954-88-3
3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C / Inert atmosphere

3.3: 24 h / 20 °C

4.1: 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydroxide; water / methanol / 5.5 h / 70 °C

6.1: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

6.2: 5 h / 20 °C

With N-Bromosuccinimide; water; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 1354904-59-8
3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}benzoic acid

: 22059-22-9,117771-39-8,118453-50-2,118464-69-0,118493-85-9,1141922-26-0,1429624-21-4
1-(hydroxyimino)ethylamine

: 1354954-88-3
3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

Guidance literature:: 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}benzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

1-(hydroxyimino)ethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1354904-59-8
3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}benzoic acid

: 118493-85-9,117771-39-8,1141922-26-0,1429624-21-4
acetamide oxime

: 530-62-1
1,1'-carbonyldiimidazole

: 1354954-88-3
3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-1-(hydroxyimino)ethyl]benzamide

Guidance literature:: 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}benzoic acid; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

acetamide oxime; In N,N-dimethyl-formamide; at 20 ℃; for 5h;