C₃₇H₅₃NO₃Si

Base Information

Chemical Name:C₃₇H₅₃NO₃Si
CAS No.:250595-74-5
Molecular Formula:C₃₇H₅₃NO₃Si
Molecular Weight:587.918
Hs Code.:

C<sub>37</sub>H<sub>53</sub>NO<sub>3</sub>Si

Synonyms:C₃₇H₅₃NO₃Si

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Chemical Property of C₃₇H₅₃NO₃Si

Chemical Property:

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Technology Process of C₃₇H₅₃NO₃Si

There total 17 articles about C₃₇H₅₃NO₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 250595-73-4
C₃₇H₅₃NO₄Si

: 250595-74-5
C₃₇H₅₃NO₃Si

Guidance literature:: C₃₇H₅₃NO₄Si; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

With Schwartz's reagent; at 20 ℃;
DOI:10.1016/S0040-4039(99)01170-3

Reference yield:

: 104115-44-8,1460-38-4
(2-oxocyclopent)acetic acid

: 250595-74-5
C₃₇H₅₃NO₃Si

Guidance literature:: Multi-step reaction with 15 steps

1.1: 95 percent / toluene / Heating

2.1: 99 percent / TiCl₄ / CH₂Cl₂ / -78 - 20 °C

3.1: 92 percent / Na; NH₃ / tetrahydrofuran; ethanol / -78 °C

4.1: 96 percent / DMAP / tetrahydrofuran

5.1: LiHMDS / tetrahydrofuran / -40 °C

5.2: 90 percent / tetrahydrofuran / -78 - 0 °C

6.1: 89 percent / LiOH; H₂O / tetrahydrofuran

7.1: NEt₃ / tetrahydrofuran

8.1: NaBH₄ / methanol

9.1: 95 percent / NEt₃; DMAP / CH₂Cl₂

10.1: 9-BBN / tetrahydrofuran

10.2: AsPh₃; Cs₂CO₃; H₂O / [Pd(dppf)Cl₂] / dimethylformamide

11.1: TFA / CH₂Cl₂

12.1: K₂CO₃ / H₂O

13.1: 86 percent / LiHMDS / tetrahydrofuran / -50 - 20 °C

14.1: 73 percent / ethanol

15.1: LiHMDS / tetrahydrofuran / 0 °C

15.2: 91 percent / [Cp₂Zr(H)Cl] / tetrahydrofuran / 20 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; ammonia; water; sodium; titanium tetrachloride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 1.1: Cyclization / 2.1: Ring cleavage / 3.1: Reduction / 4.1: Acylation / 5.1: Metallation / 5.2: Methylation / 6.1: Hydrolysis / 7.1: Acylation / 8.1: Reduction / 9.1: Etherification / 10.1: Addition / 10.2: Alkylation / 11.1: Deacylation / 12.1: Michael reaction / 13.1: Condensation / 14.1: Cyclization / 15.1: Metallation / 15.2: Reduction;
DOI:10.1002/(SICI)1521-3773(19991203)38:23<3542::AID-ANIE3542>3.0.CO;2-I

Reference yield:

: 161779-70-0
(3R,5aR,8aS)-3-phenyl-hexahydro-1-oxa-3a-aza-cyclopenta[c]pentalen-4-one

: 250595-74-5
C₃₇H₅₃NO₃Si

Guidance literature:: Multi-step reaction with 14 steps

1.1: 99 percent / TiCl₄ / CH₂Cl₂ / -78 - 20 °C

2.1: 92 percent / Na; NH₃ / tetrahydrofuran; ethanol / -78 °C

3.1: 96 percent / DMAP / tetrahydrofuran

4.1: LiHMDS / tetrahydrofuran / -40 °C

4.2: 90 percent / tetrahydrofuran / -78 - 0 °C

5.1: 89 percent / LiOH; H₂O / tetrahydrofuran

6.1: NEt₃ / tetrahydrofuran

7.1: NaBH₄ / methanol

8.1: 95 percent / NEt₃; DMAP / CH₂Cl₂

9.1: 9-BBN / tetrahydrofuran

9.2: AsPh₃; Cs₂CO₃; H₂O / [Pd(dppf)Cl₂] / dimethylformamide

10.1: TFA / CH₂Cl₂

11.1: K₂CO₃ / H₂O

12.1: 86 percent / LiHMDS / tetrahydrofuran / -50 - 20 °C

13.1: 73 percent / ethanol

14.1: LiHMDS / tetrahydrofuran / 0 °C

14.2: 91 percent / [Cp₂Zr(H)Cl] / tetrahydrofuran / 20 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; ammonia; water; sodium; titanium tetrachloride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1.1: Ring cleavage / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Methylation / 5.1: Hydrolysis / 6.1: Acylation / 7.1: Reduction / 8.1: Etherification / 9.1: Addition / 9.2: Alkylation / 10.1: Deacylation / 11.1: Michael reaction / 12.1: Condensation / 13.1: Cyclization / 14.1: Metallation / 14.2: Reduction;
DOI:10.1002/(SICI)1521-3773(19991203)38:23<3542::AID-ANIE3542>3.0.CO;2-I