N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

Base Information

• Chemical Name: N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine
• CAS No.: 358673-18-4
• Molecular Formula: C₇₂H₁₀₀N₁₀O₄
• Molecular Weight: 1169.65
• Mol file: 358673-18-4.mol

Synonyms:N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

Chemical Property of N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

There total 13 articles about N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,N',N'-trimethylenediamine (142-25-6) + 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide (413620-79-8) → N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine (358673-18-4)

Guidance literature:

N,N',N'-trimethylenediamine; 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide; With 4 Angstroem MS; In ethanol; acetic acid; at 20 ℃; for 4h;

With sodium cyanoborohydride; In ethanol; acetic acid; at 20 ℃; for 14h; Further stages.;

DOI:10.1021/jo001775t

Reference yield:

C48H44N2O4 (550372-00-4) → N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine (358673-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / tetrahydrofuran

2: 91 percent / TiCl₄ / CH₂Cl₂

3: NaBH₃CN; AcOH / ethanol

4: NH₃ / methanol

With ammonia; titanium tetrachloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)01075-4

Reference yield:

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide (358673-16-2) → N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine (358673-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / TiCl₄ / CH₂Cl₂

2: NaBH₃CN; AcOH / ethanol

3: NH₃ / methanol

With ammonia; titanium tetrachloride; sodium cyanoborohydride; acetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)01075-4

upstream raw materials:

N,N',N'-trimethylenediamine

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

C₄₈H₄₄N₂O₄

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide