Technology Process of N-(3-amino-2,4-difluorophenyl)-3-fluoropropane-1-sulfonamide
There total 5 articles about N-(3-amino-2,4-difluorophenyl)-3-fluoropropane-1-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-difluoro-3-(3-fluoropropylsulfonamido)benzoic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
With
water;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 2 h / Cooling with water bath
2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
3.1: pyridine / dichloromethane / 8 °C
4.1: potassium hydroxide; water / tetrahydrofuran / 3.5 h / 50 °C
4.2: pH 2 - 3
5.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 6 °C
5.2: 1.5 h / 80 °C
With
pyridine; methanol; diphenyl phosphoryl azide; water; hydrogen; triethylamine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
5.2: Curtius Rearrangement;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
2.1: pyridine / dichloromethane / 8 °C
3.1: potassium hydroxide; water / tetrahydrofuran / 3.5 h / 50 °C
3.2: pH 2 - 3
4.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 6 °C
4.2: 1.5 h / 80 °C
With
pyridine; diphenyl phosphoryl azide; water; hydrogen; triethylamine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
4.2: Curtius Rearrangement;
