(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

Base Information

Chemical Name:(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester
CAS No.:148671-89-0
Molecular Formula:C₂₇H₃₄N₂O₇S
Molecular Weight:530.642
Hs Code.:

Synonyms:(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

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Chemical Property of (S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

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Technology Process of (S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

There total 5 articles about (S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(2-Hydroxymethyl-benzyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-malonic acid diethyl ester

: 148671-89-0
(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1021/ja00063a015

Reference yield:

: 17360-25-7,32013-47-1,68005-71-0
N-(p-toluenesulfonyl)-L-valine

: 148671-89-0
(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / N-methylmorpholine, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) EtONa / 1.) EtOH, 2 min, 0 deg C, 2.) EtOH, from 0 deg C to RT, 2 h

3: p-toluenesulfonic acid / ethanol / 3 h / Ambient temperature

4: Ph₃P, diethylazodicarboxylate (DEAD) / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; sodium ethanolate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00063a015

Reference yield:

: 13433-00-6
diethyl aminomalonate hydrochloride

: 148671-89-0
(S)-1,2,3,4,5,7-hexahydro-3-(1-methylethyl)-2-<(4-methylphenyl)sulfonyl>-4-oxo-6H-2,5-benzodiazonine-6,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / N-methylmorpholine, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) EtONa / 1.) EtOH, 2 min, 0 deg C, 2.) EtOH, from 0 deg C to RT, 2 h

3: p-toluenesulfonic acid / ethanol / 3 h / Ambient temperature

4: Ph₃P, diethylazodicarboxylate (DEAD) / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; sodium ethanolate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00063a015