1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

Base Information

• Chemical Name: 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea
• CAS No.: 1459140-40-9
• Molecular Formula: C₁₅H₉BrN₆OS
• Molecular Weight: 401.246
• Mol file: 1459140-40-9.mol

Synonyms:1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

Chemical Property of 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

There total 1 articles about 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-(pyrid-4-yl)-1,3,4-thiadiazole (2002-04-2) + C8H3BrN2O (1261474-41-2) → 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea (1459140-40-9)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.1016/j.bmcl.2013.08.025

Reference yield:

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate (552846-17-0) + 1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea (1459140-40-9) → C23H20N8O3S

Guidance literature:

With potassium phosphate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; In water; dimethyl sulfoxide; at 100 ℃; for 3h;

DOI:10.1016/j.bmcl.2013.08.025

Reference yield:

1-(4-bromo-3-cyanophenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea (1459140-40-9) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole (476004-79-2) → 1-(3-cyano-4-(1H-pyrrol-2-yl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea (1459140-53-4)

Guidance literature:

With potassium phosphate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; In water; dimethyl sulfoxide; at 100 ℃; for 3h;

DOI:10.1016/j.bmcl.2013.08.025

upstream raw materials:

2-amino-5-(pyrid-4-yl)-1,3,4-thiadiazole

C₈H₃BrN₂O

Downstream raw materials:

1-(3-cyano-4-(1H-pyrrol-2-yl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

1-(3-cyano-4-(1H-pyrazol-4-yl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea