(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

Base Information

Chemical Name:(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine
CAS No.:1612257-17-6
Molecular Formula:C₂₄H₃₅NO₂Si
Molecular Weight:397.633
Hs Code.:

Synonyms:(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

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Chemical Property of (2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

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Technology Process of (2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

There total 4 articles about (2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: C₁₈H₂₁NO₂

: 1612257-17-6
(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol501397b

Reference yield:

: 1612257-15-4
(3S,4R,E)-5-(benzyloxy)-4-nitro-1-phenylpent-1-en-3-ol

: 1612257-17-6
(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: indium; acetic acid / tetrahydrofuran / 1.5 h / 85 - 90 °C

1.2: 2 h / 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C

With 2,6-dimethylpyridine; indium; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol501397b

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1612257-17-6
(2R,3S,E)-1-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-4-en-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: C₁₉H₁₈F₂N₂O₄; sodium hexamethyldisilazane; Nd⁽³⁺⁾*0.2O^(2-)*2.6C₃H₇O^(1-) / tetrahydrofuran / 120 h / -60 °C

2.1: indium; acetic acid / tetrahydrofuran / 1.5 h / 85 - 90 °C

2.2: 2 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 20 °C

With 2,6-dimethylpyridine; indium; Nd⁽³⁺⁾*0.2O^(2-)*2.6C₃H₇O^(1-); C₁₉H₁₈F₂N₂O₄; sodium hexamethyldisilazane; acetic acid; In tetrahydrofuran; dichloromethane; 1.1: |Aldol Addition;
DOI:10.1021/ol501397b