3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445879-03-7
Molecular Formula:C₂₈H₃₁N₅O₇S
Molecular Weight:581.649
Hs Code.:

Synonyms:3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 8 articles about 3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: methyl 3-(7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-ylamino)-5-isopropoxybenzoate

: 1445879-03-7
3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-03-7
3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

5: ethanol / 2 h / 80 °C

6: lithium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

With chlorosulfonic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1445879-84-4
7-bromo-4-chloro-N-propyl-3-quinolinesulfonamide

: 1445879-03-7
3-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(N-propylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

2: ethanol / 2 h / 80 °C

3: lithium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;