2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

Base Information

Chemical Name:2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride
CAS No.:1190644-29-1
Molecular Formula:C₂₀H₂₁ClN₂O*ClH
Molecular Weight:377.313
Hs Code.:

Synonyms:2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

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Chemical Property of 2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

Chemical Property:

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Technology Process of 2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

There total 6 articles about 2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1190644-28-0
tert-butyl [2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]carbamate

: 1190644-29-1
2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

Guidance literature:: With hydrogenchloride; In Dimethyl ether; dichloromethane; at 20 ℃;

Reference yield:

: 916923-29-0
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclopropanecarboxamide

: 1190644-29-1
2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 72 h / Reflux

1.2: Cooling with ice

2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h

3.2: 72 h / 20 °C

4.1: hydrogenchloride / Dimethyl ether; dichloromethane / 20 °C

With hydrogenchloride; boron tribromide; sodium hydride; trichlorophosphate; In Dimethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1190644-26-8
1-[1-(4-chlorophenyl)cyclopropyl]-7-methoxy-3,4-dihydroisoquinoline

: 1190644-29-1
2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h

2.2: 72 h / 20 °C

3.1: hydrogenchloride / Dimethyl ether; dichloromethane / 20 °C

With hydrogenchloride; boron tribromide; sodium hydride; In Dimethyl ether; dichloromethane; N,N-dimethyl-formamide;