3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

Base Information

Chemical Name:3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole
CAS No.:130824-83-8
Molecular Formula:C₂₁H₂₁BrN₂
Molecular Weight:381.315
Hs Code.:

Synonyms:3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

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Chemical Property of 3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

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Technology Process of 3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

There total 1 articles about 3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 100-44-7
benzyl chloride

: 130824-82-7
8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

: 130824-83-8
3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

Guidance literature:: With triethylamine; In acetonitrile; for 2h; Heating;
DOI:10.1007/BF00766469

Reference yield:

: 130824-83-8
3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

: 105-58-8,76619-83-5
Diethyl carbonate

: 180639-69-4
3-benzyl-8-ethoxycarbonyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

Guidance literature:: 3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole; With lithium; In tetrahydrofuran; at 0 ℃; for 1h;

Diethyl carbonate; In tetrahydrofuran; at -10 ℃; for 0.5h;
DOI:10.1007/BF02333964

Reference yield:

: 130824-83-8
3-benzyl-8-bromo-2,3,3a,4,5,6-hexahydro-1H-pyrazino<3,2,1-j,k>carbazole

: 3-benzyl-8-carboxy-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Li / tetrahydrofuran / 1 h / 0 °C

1.2: tetrahydrofuran / 0.5 h / -10 °C

2.1: 70 percent / KOH / ethanol; H₂O / 3 h / Heating

With potassium hydroxide; lithium; In tetrahydrofuran; ethanol; water; 1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis;
DOI:10.1007/BF02333964