6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

Base Information

Chemical Name:6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide
CAS No.:1262845-07-7
Molecular Formula:C₂₀H₂₃N₇O
Molecular Weight:377.449
Hs Code.:

Synonyms:6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

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Chemical Property of 6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

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Technology Process of 6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

There total 3 articles about 6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262846-93-4
6-{3-[4-(4-methylpiperazin-1-yl)phenyl]-3-oxopropionyl}pyridine-2-carboxylic acid methyl ester

: 1262845-07-7
6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; hydrazine; In ethanol; for 12h; Reflux;

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1262845-07-7
6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 20 °C / Heating

2: sodium methylate / tetrahydrofuran; methanol / 20 °C / Cooling with ice

3: hydrazine; N-ethyl-N,N-diisopropylamine / ethanol / 12 h / Reflux

With sodium methylate; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;

Reference yield:

: 26586-55-0
1-[4-(4-methylpiperazin-1-yl)phenyl]ethanone

: 1262845-07-7
6-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazol-3-yl}pyridine-2-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / tetrahydrofuran; methanol / 20 °C / Cooling with ice

2: hydrazine; N-ethyl-N,N-diisopropylamine / ethanol / 12 h / Reflux

With sodium methylate; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; ethanol;