(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

Base Information

Chemical Name:(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one
CAS No.:69060-87-3
Molecular Formula:C₂₀H₂₇NO
Molecular Weight:297.44
Hs Code.:

Synonyms:(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

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Chemical Property of (4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

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Technology Process of (4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

There total 10 articles about (4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 80471-51-8
N-benzyl-2-aza-7-(2-propionyl)-8-methylbicyclo<4.4.0>dec-1(6)-ene

: 69060-87-3
(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

Guidance literature:: With hydrogenchloride; In methanol; for 48h; Heating;
DOI:10.1021/ja00368a024

Reference yield: 52.0%

: 69060-86-2,69088-61-5,72002-83-6
(7SR,9RS)-N-(phenylmethyl)-9-methyl-7-<(2-methyl-1,3-dioxolan-2-yl)methyl>-1,4-dioxaspiro<4.5>decan-6-propanamine

: 80471-51-8
N-benzyl-2-aza-7-(2-propionyl)-8-methylbicyclo<4.4.0>dec-1(6)-ene

: 69060-87-3
(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

Guidance literature:: With hydrogenchloride; In methanol; for 48h; Heating;
DOI:10.1021/ja00368a024

Reference yield:

: 69060-78-2
2-(2-cyanoethyl)-5-methylcyclohex-2-en-1-one

: 69060-87-3
(4aRS,5SR,8aSR,10RS)-10-methyl-1-(phenylmethyl)hexahydro-1H-5,8a-propanoquinolin-7(8H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / titanium tetrachloride / CH₂Cl₂ / 0.5 h / -78 °C

2: 83 percent / O₃ / methanol / 0.28 h / -78 °C

3: 99 percent / p-TsOH*H₂O / benzene / 6 h / Heating

4: 97.5 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

5: 98 percent / Et₃N / benzene / 12 h / Ambient temperature

6: 96 percent / LiAlH₄ / diethyl ether / 48 h / Ambient temperature

7: 100 percent / 10percent HCl / diethyl ether

8: 66 percent / 3M HCl / methanol / 48 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; titanium tetrachloride; toluene-4-sulfonic acid; ozone; triethylamine; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00368a024