3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide

Base Information

• Chemical Name: 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide
• CAS No.: 1416233-43-6
• Molecular Formula: C₂₉H₂₂Cl₂N₂O₅
• Molecular Weight: 549.41
• Mol file: 1416233-43-6.mol

Synonyms:3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide

Chemical Property of 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide

There total 5 articles about 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

9b-amino-4b-hydroxy-7-isopropyl-4b,9b-dihydro-10H-indeno[1,2-b]benzofuran-10-one (1416231-32-7) + 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride (4462-55-9) → 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide (1416233-43-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

3-isopropylhydroxybenzene (618-45-1) → 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide (1416233-43-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 2 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

3: ammonia / tetrahydrofuran; isopropyl alcohol / 5 - 20 °C

4: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; ammonia; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

Reference yield:

4b,9b-dihydroxy-7-isopropyl-4b,9b-dihydro-5-oxa-indeno[2,1-a]-inden-10-one (1416230-61-9) → 3-(2,6-dichlorophenyl)-N-(4b-hydroxy-7-isopropyl-10-oxo-9b,10-dihydro-4bH-benzo[d]indeno[1,2-b]furan-9b-yl)-5-methylisooxazole-4-carboxamide (1416233-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2: ammonia / tetrahydrofuran; isopropyl alcohol / 5 - 20 °C

3: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; ammonia; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

upstream raw materials:

9b-chloro-4b-hydroxy-7-isopropyl-4b,9b-dihydro-10H-indeno[1,2-b]benzofuran-10-one

9b-amino-4b-hydroxy-7-isopropyl-4b,9b-dihydro-10H-indeno[1,2-b]benzofuran-10-one

3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride

3-isopropylhydroxybenzene