Technology Process of 3-[trans-2-(4-fluorophenyl)vinyl]-5-(1-methoxymethyl-propoxy)-N-(thiazol-2-yl)-benzamide
There total 11 articles about 3-[trans-2-(4-fluorophenyl)vinyl]-5-(1-methoxymethyl-propoxy)-N-(thiazol-2-yl)-benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-thiazolylamine; 3-[trans-2-(4-fluorophenyl)vinyl]-5-(1-methoxymethyl-propoxy)-benzoic acid methyl ester;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
With
hydrogenchloride;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 150 °C
2.1: potassium hydroxide; methanol / 12 h / 100 °C
3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
3.2: 3 h / 0 °C
4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C
5.1: 3 h / 160 °C
6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 17 h / 20 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
8.1: trifluoroacetic acid; methyl-phenyl-thioether / 12 h / 20 °C
9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C
With
methanol; borane-THF; methyl-phenyl-thioether; di-isopropyl azodicarboxylate; tribromide phosphate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide;
18-crown-6 ether;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium hydroxide; methanol / 12 h / 100 °C
2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
2.2: 3 h / 0 °C
3.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C
4.1: 3 h / 160 °C
5.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 17 h / 20 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
7.1: trifluoroacetic acid; methyl-phenyl-thioether / 12 h / 20 °C
8.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C
With
methanol; borane-THF; methyl-phenyl-thioether; di-isopropyl azodicarboxylate; tribromo phosphate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide;
18-crown-6 ether;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
