Tamaulipin B

Base Information

Chemical Name:Tamaulipin B
CAS No.:18045-83-5
Molecular Formula:C15H20O3
Molecular Weight:248.3175
Hs Code.:
NSC Number:135019
DSSTox Substance ID:DTXSID00419219
Mol file:18045-83-5.mol

Synonyms:Tamaulipin B;Hanphillin;18045-83-5;3alpha-Hydroxycostunolide;(6Z,10E)-9-hydroxy-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one;NSC135019;DTXSID00419219;AKOS040740290;NSC-135019

Suppliers and Price of Tamaulipin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tamaulipin B

Chemical Property:

Vapor Pressure:1.26E-09mmHg at 25°C
Boiling Point:440.9°Cat760mmHg
Flash Point:187.8°C
PSA：46.53000
Density:1.11g/cm³
LogP:2.52160
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:248.14124450
Heavy Atom Count:18
Complexity:431

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CCC(C(=CC2C(CC1)C(=C)C(=O)O2)C)O
Isomeric SMILES:C/C/1=C/CC(/C(=C/C2C(CC1)C(=C)C(=O)O2)/C)O

Technology Process of Tamaulipin B

There total 8 articles about Tamaulipin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 110990-50-6,111137-16-7
(6E,10Z)-(3aR,9R,11aR)-9-(tert-Butyl-dimethyl-silanyloxy)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-2-one

: 18045-83-5,60268-40-8,65556-51-6,93603-64-6,111058-22-1
<3R,6R,7R,1(10)E,4Z>-3-hydroxy-1(10),4,11(13)-germacratrieno-12,6-lactone

Guidance literature:: With tetrabutyl ammonium fluoride;
DOI:10.1246/cl.1986.1879

Reference yield:

: 110990-48-2,110990-58-4
(6E,10Z)-(3aR,9R,11aS)-9-(tert-Butyl-dimethyl-silanyloxy)-6,10-dimethyl-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-2-one

: 18045-83-5,60268-40-8,65556-51-6,93603-64-6,111058-22-1
<3R,6R,7R,1(10)E,4Z>-3-hydroxy-1(10),4,11(13)-germacratrieno-12,6-lactone

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / LDA

2: 45 percent / MsCl, 4-dimethylaminopyridine / pyridine

3: 85 percent / tetrabutylammonium fluoride

With dmap; tetrabutyl ammonium fluoride; methanesulfonyl chloride; lithium diisopropyl amide; In pyridine;
DOI:10.1246/cl.1986.1879

Reference yield:

: 110990-48-2,110990-58-4
(6E,10Z)-(3aS,9S,11aR)-9-(tert-Butyl-dimethyl-silanyloxy)-6,10-dimethyl-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-2-one

: 18045-83-5,60268-40-8,65556-51-6,93603-64-6,111058-22-1
(-)-4,5-cis-3β-hydroxygemacranolide

Guidance literature:: Multi-step reaction with 3 steps

1: LDA

2: MsCl, 4-dimethylaminopyridine / pyridine

3: tetrabutylammonium fluoride

With dmap; tetrabutyl ammonium fluoride; methanesulfonyl chloride; lithium diisopropyl amide; In pyridine;
DOI:10.1246/cl.1986.1879