1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid
CAS No.:1251529-11-9
Molecular Formula:C₁₈H₂₃ClN₂O₃
Molecular Weight:350.845
Hs Code.:

Synonyms:1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Suppliers and Price of 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

There total 10 articles about 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1251529-07-3
1-(4-chloro-3-methyl-benzyl)-piperidin-4-one

: 13515-99-6,23150-65-4,27025-25-8
D-glutamic acid dimethyl ester hydrochloride

: 1251529-11-9
1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: 1-(4-chloro-3-methyl-benzyl)-piperidin-4-one; D-glutamic acid dimethyl ester hydrochloride; With sodium methylate; In methanol; ethanol; at 22 ℃; for 0.25h; Large scale;

With platinum(IV) oxide; hydrogen; acetic acid; In methanol; ethanol; at 50 - 80 ℃; under 2250.23 - 3000.3 Torr; Large scale;

Reference yield:

: C₁₉H₂₅ClN₂O₂

: 1251529-11-9
1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: C₁₉H₂₅ClN₂O₂; With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 1251529-10-8
C₁₉H₂₅ClN₂O₃

: 1251529-11-9
1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: C₁₉H₂₅ClN₂O₃; With lithium hydroxide; In 1,4-dioxane; water; at 25 ℃;

With hydrogenchloride; In 1,4-dioxane; water;