(R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester

Base Information

• Chemical Name: (R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester
• CAS No.: 77257-13-7
• Molecular Formula: C₁₆H₂₂O₅
• Molecular Weight: 294.348
• Mol file: 77257-13-7.mol

Synonyms:(R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester

Chemical Property of (R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester

There total 1 articles about (R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate (58846-71-2) → (R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester (77257-13-7)

Guidance literature:

With iron(III) chloride; In methanol; diethyl ether; water; for 0.5h;

DOI:10.1021/jo00325a004

Reference yield: 100.0%

(R)-3-Hydroxy-3-methyl-5-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid methyl ester (77257-13-7) → (R)-5-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-3-hydroxy-3-methyl-pentanoic acid methyl ester (77257-15-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jo00325a004

upstream raw materials:

(-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate

Downstream raw materials:

(R)-5-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-3-hydroxy-3-methyl-pentanoic acid methyl ester