Mafenide hydrochloride

Base Information

• Chemical Name: Mafenide hydrochloride
• CAS No.: 138-37-4
• Molecular Formula: C7H10N2O2S^.HCl
• Molecular Weight: 222.696
• Hs Code.: 29350090
• European Community (EC) Number: 205-325-3
• NSC Number: 757093,3527
• UNII: 3J751V0284
• DSSTox Substance ID: DTXSID6045296
• Wikidata: Q27257294
• NCI Thesaurus Code: C76107
• Pharos Ligand ID: TKLJJ81FKP8G
• ChEMBL ID: CHEMBL1593568
• Mol file: 138-37-4.mol

Synonyms:4 Homosulfanilamide;4-Homosulfanilamide;Bensulfamide;Mafenide;Mafenide Acetate;Mafylon;Maphenid;Marfanil;Napaltan;Sulfabenzamine;Sulfamylon

Chemical Property of Mafenide hydrochloride

Chemical Property:

• Melting Point: 261-263 °C(lit.)
• Boiling Point: 382 °C at 760 mmHg
• Flash Point: 184.8 °C
• PSA: 94.56000
• LogP: 3.07610
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.0229765
• Heavy Atom Count: 13
• Complexity: 224

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Aminomethylbenzenesulfonamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N.Cl
• Uses: Antibacterial;Inhibitor of folic acid biosynthesis

Technology Process of Mafenide hydrochloride

There total 1 articles about Mafenide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ mafenide hydrochloride (138-37-4)

Guidance literature:

N-Benzyliden-p-aminomethyl-benzolsulfonamid (XVIII), 36percentig. HCl;

DOI:10.1007/BF00758509

Reference yield: 97.0%

2,6-dichloropyrido[3,2-d]pyrimidin-4-ol (1036738-13-2) + mafenide hydrochloride (138-37-4) → 4-[(6-chloro-4-hydroxy-pyrido[3,2-d]pyrimidin-2-ylamino)-methyl]-benzenesulfonamide (1036738-14-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 110 - 120 ℃; for 3h;

Reference yield: 95.0%

C21H23N5O4S + mafenide hydrochloride (138-37-4) → benzyl (S)-(4-(methylthio)-1-oxo-1-((2-oxo-2-((4-sulfamoylbenzyl)amino)ethyl)amino)butan-2-yl)carbamate

Guidance literature:

With triethylamine; In tetrahydrofuran; at 70 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bioorg.2018.08.032

Downstream raw materials:

5-methyl-isoxazole-3-carboxylic acid 4-sulfamoyl-benzylamide

3-methyl-isoxazole-5-carboxylic acid 4-sulfamoyl-benzylamide

L-2-Carbobenzoxyamino-2-carbethoxyethan-N-homosulfanilylamidosulfonamid

5-(4-Sulfamoyl-benzylcarbamoyl)-pentanoic acid methyl ester