N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide

Base Information

• Chemical Name: N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide
• CAS No.: 201848-21-7
• Molecular Formula: C₃₃H₃₅N₃O₄
• Molecular Weight: 537.659

Synonyms:N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide

Chemical Property of N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide

There total 3 articles about N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(1-{(1R,3S,4R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-trityloxymethyl-cyclopentyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide → N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide (201848-21-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 14h;

DOI:10.1080/07328319708002566

Reference yield:

N6-isobutyrylaminocytosine (97626-98-7) → N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide (201848-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / PPh₃, DEAD / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 18 h

2: 93 percent / TBAF / tetrahydrofuran / 14 h / 25 °C

With tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1080/07328319708002566

Reference yield:

(1S,3S,4R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-trityloxymethyl-cyclopentanol (167260-21-1) → N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide (201848-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / PPh₃, DEAD / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 18 h

2: 93 percent / TBAF / tetrahydrofuran / 14 h / 25 °C

With tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1080/07328319708002566

upstream raw materials:

N⁶-isobutyrylaminocytosine

(1S,3S,4R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-trityloxymethyl-cyclopentanol

Downstream raw materials:

Acetic acid (1S,2R,4R)-4-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-2-trityloxymethyl-cyclopentyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 201848-21-7 N-[1-((1R,3S,4R)-3-Hydroxy-4-trityloxymethyl-cyclopentyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-isobutyramide

Send

Send

Metric Ton KG G Pound L ML

Send

Send