4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide

Base Information

• Chemical Name: 4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide
• CAS No.: 1256382-71-4
• Molecular Formula: C₂₄H₂₃F₃N₂O₂
• Molecular Weight: 428.454

Synonyms:4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide

Chemical Property of 4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide

There total 5 articles about 4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid (1256382-48-5) + 3-trifluoromethylaniline (98-16-8) → 4-oxo-1-pentyl-6-phenyl-N3-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide (1256382-71-4)

Guidance literature:

4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

3-trifluoromethylaniline; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jm100286k

Reference yield:

ethyl 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylate (1256382-37-2) → 4-oxo-1-pentyl-6-phenyl-N3-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide (1256382-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 6 h / Reflux

1.2: pH 2

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm100286k

Reference yield:

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate (134653-70-6,51145-57-4) → 4-oxo-1-pentyl-6-phenyl-N3-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide (1256382-71-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

1.2: 0.75 h / 20 °C

2.1: acetic acid / ethanol / 5 °C / Reflux

3.1: sodium hydroxide / ethanol / 6 h / Reflux

3.2: pH 2

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

4.2: 12 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm100286k

upstream raw materials:

ethyl 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylate

4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid

3-trifluoromethylaniline

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1256382-71-4 4-oxo-1-pentyl-6-phenyl-N₃-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send